Fig. 2
From: A network medicine approach to study comorbidities in heart failure with preserved ejection fraction
Comparison of comorbidity profiles in heart failure subtypes. A Scheme of analysis. EH essential hypertension, CAD coronary artery disease, DMII diabetes mellitus type II, RA rheumatoid arthritis. B Multiple correspondence analysis of comorbidity profiles of HFpEF and HFrEF cohort. MCA dimensions were tested for association with clinical covariates and summed up to estimate total explained variance. C Proportions of the sum of parameter estimates of top 100 comorbidities of the patient classifier model, colored by disease categories. D Top 50 comorbidities of the patient classifier. The parameters are the absolute fitted values of the coefficients in the elastic net model for each comorbidity of the patient classifier separated by association to HFpEF (top) or HFrEF features (bottom). Colors indicate disease category using the same color legend as in B