Fig. 5

HFpEF gene prediction. A AUROC and AUC-PR for different HF-related gene sets in random walk probability vectors based on HFpEF and HFrEF comorbidity profiles. Prior knowledge gene sets are DisGeNET, Kegg pathway for dilated cardiomyopathy (DCM), cardiomyopathy (literature curated). Data-based gene sets are PheWAS, ReHeaT, and GWAS variants. B Prioritizing genes for HFpEF that are close to HFpEF comorbidity profiles in the HFhetnet and also display high ranking differences when compared to gene predictions based on HFrEF comorbidity profiles. C Scheme of experimental design for murine model of HFpEF by HFD/L-NAME diet. Cardiac ventricles were harvested after 9 weeks and bulk transcriptomics were collected. D Volcano plot displaying gene expression regulation in the murine HFpEF model compared to control. Labeled genes display HFpEF predicted genes from human comorbidity profiles. E Predicted HF genes from comorbidity analysis were enriched in gene-level t-statistics of murine differentially expression analysis comparing disease with control. Gene set enrichment p-value. ***p < 0.001. **p < 0.01