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Table 1 Clinical characteristics of HFrEF, HFmrEF, and HFpEF cohorts. Descriptive statistics of HFrEF, HFmrEF and HFpEF cohorts. F female, m male, BMI body mass index, BP blood pressure, LDL low-density lipoprotein, HDL high-density lipoprotein, ICD implantable cardioverter defibrillator, PCI percutaneous coronary intervention, NT-BNP N-terminal pro b-type natriuretic peptide. All numerical values are median (IQR), Elixhauser index is mean (SD)

From: A network medicine approach to study comorbidities in heart failure with preserved ejection fraction

   

HF subtypes

  

Variable

N

Overall

HFpEF

HFmrEF

HFrEF

p-value*

p-value+

  

(N = 17,665)

(N = 8062)

(N = 3018)

(N = 6585)

  

Sex

17,617

    

 < 0.001

 < 0.001

 Female

 

5247 (30%)

2822 (35%)

790 (26%)

1635 (25%)

  

 Male

 

12,370 (70%)

5228 (65%)

2218 (74%)

4924 (75%)

  

Age (years)

17,665

70 (60, 78)

70 (61, 78)

70 (59, 77)

70 (60, 78)

0.093

0.5

BMI

9132

26.8 (24.2, 30.0)

26.8 (24.2, 30.0)

26.9 (24.2, 29,9)

26.5 (24.1, 30.1)

0.08

0.9

Systolic BP (mmHg)

5146

148 (134, 160)

150 (139, 164)

148 (135, 160)

140 (127, 154)

 < 0.001

 < 0.001

Diastolic BP (mmHg)

5146

84 (76, 92)

85 (78, 93)

84 (76, 93)

82 (73, 90)

 < 0.001

 < 0.001

LDL (mg/dL)

12,270

87 (69, 110)

88 (69, 110)

91 (72, 113)

84 (67, 106)

 < 0.001

 < 0.001

HDL (mg/dL)

12,368

44 (36, 54)

46 (38, 56)

43 (36, 53)

40 (34, 50)

 < 0.001

 < 0.001

Triglycerides (mg/dL)

13,859

112 (85, 153)

112 (85, 151)

112 (85, 156)

113 (85, 156)

0.11

0.006

Cholesterol (mg/dL)

13,577

160 (135, 188)

163 (138, 190)

164 (140, 192)

153 (129, 183)

 < 0.001

 < 0.001

N PheCodes

17,665

13 (8, 21)

13 (9,21)

12 (7, 19)

14 (9, 22)

 < 0.001

0.088

Elixhauser Index

17,665

5.39 (2.72)

5.36 (2.68)

5.09 (2.70)

5.56 (2.76)

 < 0.001

 < 0.001

Intubated

17,665

1766 (10.0%)

552 (6.8)

257 (8.5%)

957 (15%)

 < 0.001

 < 0.001

ICD Implantation

17,665

3213 (18%)

1007 (12%)

468 (16%)

1738 (26%)

 < 0.001

 < 0.001

PCI

17,665

9116 (52%)

4267 (53%)

1554 (51%)

3295 (50%)

0.002

 < 0.001

log (NT-BNP)

6169

2.99 (2.45, 3.53)

3.07 (2.53, 3.55)

3.07 (2.53, 3.55)

3.45 (2.96, 3.88)

 < 0.001

 < 0.001

  1. All continuous values displayed as median (IQR) except for Elixhauser index which is mean (SD). All dichotomous values displayed as N (%)
  2. *Kruskal–Wallis p-value across all subtypes
  3. +Wilcoxon–rank sum or chi-squared p-value for HFpEF vs HFrEF
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BMC Medicine

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