Table 2 Overview of disease clusters. Manual labeling of disease clusters (DC) by characterizing most central and prevalent diseases in each cluster. EH essential hypertension, MI myocardial infarction, COPD chronic obstructive pulmonary disease, CAD coronary artery disease, DM II diabetes mellitus type II, CKD chronic kidney disease, RA rheumatoid arthritis
From: A network medicine approach to study comorbidities in heart failure with preserved ejection fraction
DC | Label | Important nodes |
|---|---|---|
DC1 | Cardiac/endocrine/respiratory diseases | EH, MI, COPD, hyperlipidemia, hypothyroidism, CAD |
DC2 | Sensory/ophthalmologic/skin disease | Cataract, macular degeneration, melanomas of skin |
DC3 | Cardiovascular disease with heart focus | Valve disease, congenital anomalies, arrhythmias |
DC4 | Vascular/renal/diabetic diseases | DM II, CKD, atherosclerosis |
DC5 | Critical illness/complications | Infectious disease, organ failures |
DC6 | Rheumatoid/osteological/psychiatric diseases | Osteoporosis, osteopenia, RA, depression |
DC7 | Gastroenterological diseases | Gastritis, diverticulitis, cirrhosis |
DC8 | Neoplastic/hematopoietic diseases | Breast cancer, aplastic anemia, lymphomas |
DC9 | Neurological/vascular neurological diseases | Stroke, dementias, epilepsy |