Fig. 5
From: Progressive trajectories of schizophrenia across symptoms, genes, and the brain
Enriched networks in the discovery and replication cohorts. A Overlapping genes between the discovery and replication cohorts. B Enrichment network using merged PLS1 (|Z|> 5) genes from the discovery and replication cohorts. The top three terms (with the smallest p-values) were “dopaminergic synapse” (− log10(p) = 12.39), “pathways of neurodegeneration-multiple diseases” (− log10(p) = 11.40), and “pathways in cancer” (− log10(p) = 10.85). C Protein–protein interaction network using merged PLS1 (|Z|> 5) genes, including 13 MCODE networks. Each color represents one MCODE network. The top right table shows the top three enriched terms, which were identified using Gene Ontology enrichment analysis for each MCODE network