Skip to main content

Table 1 Baseline characteristics of study population according to the quartiles of dietary inflammatory index

From: Association of pro-inflammatory diet with increased risk of all-cause dementia and Alzheimer's dementia: a prospective study of 166,377 UK Biobank participants

Characteristics

Overall

Dietary inflammatory indexa

P valueb

First quartile (n = 41,587)

Second quartile (n = 41,607)

Third quartile (n = 41,587)

Fourth quartile (n = 41,596)

Age (mean ± SD)

55.91 ± 7.98

56.91 ± 7.83

56.20 ± 7.91

55.71 ± 7.95

54.82 ± 8.08

 < 0.001

Female sex (%)

88,802 (53.4)

20,653 (49.7)

21,656 (52.0)

22,474 (54.0)

24,019 (57.7)

 < 0.001

Ethnic (%)

     

 < 0.001

 White

159,256 (95.7)

39,970 (96.1)

40,324 (96.9)

40,060 (96.3)

38,902 (93.5)

 

 Asian

2398 (1.4)

489 (1.2)

397 (1.0)

546 (1.3)

966 (2.3)

 

 Black

2018 (1.2)

457 (1.1)

328 (0.8)

377 (0.9)

856 (2.1)

 

 Chinese

470 (0.3)

125 (0.3)

94 (0.2)

112 (0.3)

139 (0.3)

 

 Mixed

1037 (0.6)

249 (0.6)

232 (0.6)

209 (0.5)

347 (0.8)

 

 Other

1198 (0.7)

297 (0.7)

232 (0.6)

283 (0.7)

386 (0.9)

 

Education level (%)

     

 < 0.001

 Higher education qualifications/professional qualifications

118,527 (71.2)

30,727 (73.9)

30,822 (74.1)

29,621 (71.2)

27,357 (65.8)

 

 Others

47,850 (28.8)

10,860 (26.1)

10,785 (25.9)

11,966 (28.8)

14,239 (34.2)

 

TDI (mean ± SD)

 − 1.58 ± 2.86

 − 1.68 ± 2.81

 − 1.75 ± 2.76

 − 1.62 ± 2.84

 − 1.27 ± 3.02

 < 0.001

Smoking status (%)

     

 < 0.001

 Never

93,931 (56.5)

23,560 (56.7)

23,926 (57.5)

23,408 (56.3)

23,037 (55.4)

 

 Previous

59,476 (35.7)

15,501 (37.3)

15,008 (36.1)

14,953 (36.0)

14,014 (33.7)

 

 Current

12,970 (7.8)

2526 (6.1)

2673 (6.4)

3226 (7.8)

4545 (10.9)

 

Drinking status (%)

     

 < 0.001

 Never

5097 (3.1)

1132 (2.7)

1052 (2.5)

1158 (2.8)

1755 (4.2)

 

 Previous

4955 (3.0)

1140 (2.7)

1056 (2.5)

1159 (2.8)

1600 (3.8)

 

 Current

156,325 (94.0)

39,315 (94.5)

39,499 (94.9)

39,270 (94.4)

38,241 (91.9)

 

BMI (%)

     

 < 0.001

 Health weight

61,871 (37.2)

16,472 (39.6)

16,114 (38.7)

15,205 (36.6)

14,080 (33.8)

 

 Underweight

908 (0.5)

236 (0.6)

247 (0.6)

194 (0.5)

231 (0.6)

 

 Overweight

69,587 (41.8)

17,196 (41.3)

17,443 (41.9)

17,551 (42.2)

17,397 (41.8)

 

 Obesity

34,011 (20.4)

7683 (18.5)

7803 (18.8)

8637 (20.8)

9888 (23.8)

 

Diabetes (%)

6847 (4.1)

1742 (4.2)

1570 (3.8)

1671 (4.0)

1864 (4.5)

 < 0.001

Blood pressure status (%)

     

 < 0.001

 Normal

27,949 (16.8)

6415 (15.4)

6873 (16.5)

6964 (16.7)

7697 (18.5)

 

 Elevated

22,181 (13.3)

5527 (13.3)

5671 (13.6)

5485 (13.2)

5498 (13.2)

 

 Hypertension stage 1

45,944 (27.6)

11,271 (27.1)

11,392 (27.4)

11,664 (28.0)

11,617 (27.9)

 

 Hypertension stage 2

70,303 (42.3)

18,374 (44.2)

17,671 (42.5)

17,474 (42.0)

16,784 (40.4)

 

Achieve the recommended physical activity level (%)

136,169 (81.8)

35,905 (86.3)

34,399 (82.7)

33,445 (80.4)

32,420 (77.9)

 < 0.001

Energy, kcal/day (mean ± SD)

2075.06 ± 606.00

2477.95 ± 666.68

2189.28 ± 498.79

1977.78 ± 448.94

1655.27 ± 461.69

 < 0.001

Family history of dementia (%)

21,800 (13.1)

5782 (13.9)

5603 (13.5)

5369 (12.9)

5046 (12.1)

 < 0.001

  1. TDI Townsend deprivation index, BMI Body mass index, SD Standard deviation
  2. aQuartiles of dietary inflammation index. The cutoff points of the quartiles are − 1.799, − 0.395, 0.985
  3. bAnalysis of variance or χ2 test where appropriate