Fig. 1
Genetic analyses of VRK2 with major depression. A Genetic associations of SNPs spanning VRK2 region with major depression in European GWAS, and the epigenome signatures in human brains and cell types, lead to identification of a “potential regulatory region” and a regulatory SNP (rs2678907). A physical map of the region is given and depicts known genes within the region, and the LD is defined based on the SNP rs1568452. NPC, neural progenitor cells. B Association results of the 3 tested VRK2 SNPs with major depression in European and Han Chinese samples. C The linkage disequilibrium (LD) maps of the 3 tested VRK2 SNPs in European and Han Chinese individuals from 1000 Genomes Project. The figure was generated using the Haploview software, and the LD of the tested SNPs was calculated using r2 algorithm implemented in the Haploview program