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Fig. 2 | BMC Medicine

Fig. 2

From: Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice

Fig. 2

Effects of rs2678907 on enhancer activities and VRK2 mRNA expression. A Results of the reporter gene assay testing the regulatory activities of rs2678907 in SK-N-SH, U251, and HEK293T cell lines. “Negative control” means pGL3 basic empty vector (which does not have promoter activity). “Empty pGL3 vector” means pGL3 promoter empty vector (which has an internal promoter). The Y-axis values represent fold changes of luciferase activity relative to the “Empty pGL3 vector” group. The means and SD of at least three biological replicates are shown. B Expression quantitative trait loci (eQTL) analyses of rs2678907 with VRK2 mRNA in the CommonMind DLPFC (left), BrainSeq caudate nucleus (middle), and Braineac frontal cortex (right) tissues. The affective or bipolar cases in the eQTL datasets were not overlapped with the samples included in the meta-analysis of European GWAS samples

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BMC Medicine

ISSN: 1741-7015

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