Fig. 2

Hazard ratios for the association between eczema/psoriasis and anxiety or depression from stratified Cox models. Three models were developed for each exposure-outcome association with varying levels of adjustment. The crude model adjusted for matched set only (age, sex, practice). The confounder-adjusted model additionally adjusted for deprivation, calendar period, asthma (in eczema) or psoriatic arthropathy (in psoriasis), and Charlson comorbidity index. The mediator-adjusted model additionally adjusted for BMI (as evidence of obesity), smoking status, harmful alcohol use. Mediator-adjusted models in the eczema cohort additionally adjusted for sleep problems and immediate risk following a prescription of high-dose oral glucocorticoids. Dots; estimated HR. Lines; 95% CI. Text shows (the number of individuals in the model) HR, [95% CI]