Fig. 2

Baseline global methylation status of tumor samples are associated with clinicopathologic features. A Unsupervised hierarchical clustering of the hypermethylation ratios of tumor tissues. The clinical details of each patient were annotated above including pathologically-evaluated risk of recurrence, radiological features, tumor diameter, pathological stage, tumor cell percentage of the tumor sample, age, and smoking status. B-D Violin plots comparing the distribution of the hypermethylation ratio according to the pathological stage (B), pathological risk (C), and radiological features characterized either as solid nodule (solid) or mixed ground-glass opacity (mix) (D). Kruskal–Wallis H test (B) or Wilcoxon signed-rank test (C-D) was performed to compare the difference between groups. Statistical significance was defined as P-value < 0.05