Fig. 4

Risk assessment by somatic mutation and timMRD score in two independent cohorts. A Schematic diagram illustrating the analytical procedures in the MEDAL cohort (n = 195) and the DYNAMIC cohort (n = 36). B-C, E Kaplan–Meier analysis of disease-free survival (DFS, expressed in days) according to ctDNA mutation status (B) and timMRD scores (C) at postoperative time points (Plasma B/C) of MEDAL (B, C) and DYNAMIC (E) cohorts. The patients were classified according to their tumor-informed ctDNA mutation status and timMRD scores of Plasma B or Plasma C. The DFS of each patient was computed from the date of surgery until radiological confirmation of disease relapse. Tick marks indicate patients who were disease-free at data cut-off date. The risk table below the KM plot summarizes the number of patients included per time point. KM survival analysis was performed with log-rank statistics to compare the survival between the two subgroups. Hazard ratio (HR) and corresponding 95% confidence intervals (CI) were computed using univariable Cox proportional-hazards regression model. D Forest plot summarizing the results of the multivariable analysis for DFS of the MEDAL cohort. Multivariable Cox proportional-hazards regression model was performed to compute the HR and corresponding 95% CI