Fig. 2

CSF1R facilitated a negative association of the superior frontal gyrus with PSSsum in HCs but not FES patients. (A) PSSsum (n = 51 + 46). (B) Correlation of PANSSt and PSSsum in FES patients (Spearman’s correlation). (C) Exemplary MRI images, color gradient is based on the statistical F values (detailed in Table 2) of group comparison. (D) Volume of the superior frontal gyrus and (E) Volume of the parahippocampal gyrus. (F) Blood CSF1R mRNA level fully moderated the negative association of the superior frontal gyral volume (independent variable) with the PSSsum score (dependent variable), controlled by age, sex, and ICV in HCs. Data presented as mean ± SEM; * FDR or p < 0.05 (ANCOVA). See also Figure S1. CSF1R: colony stimulating factor 1 receptor; DEGs: differentially expressed genes; FES: First episode schizophrenia; HCs: healthy controls; PSSsum: perceived stress scale summation score