Transcriptional level of inflammation markers associates with short-term brain structural changes in first-episode schizophrenia

Table 6 Correlation between structural changes and gene expression of antipsychotic treatment response and inflammation in patients (SZ) and controls (HC)

Neuroimaging	Study	Gene set of interests	SZ		HC
Neuroimaging	Study	Gene set of interests	r value	p value	r value	p value
Cortical thickness change	Yu et al. (2018) [31]	Antipsychotics	0.159	0.370	− 0.327	0.059
	Nalls et al. (2011) [29]	Leukocyte	− 0.019	0.913	− 0.250	0.154
		Neutrophil	0.173	0.328	− 0.169	0.340
		Basophil	0.384	0.025	0.063	0.721
		Monocyte	0.544	8.8 × 10⁻⁴	− 0.054	0.762
		Lymphocytes	0.039	0.827	− 0.305	0.079
	Keller et al. (2014) [30]	Leukocyte	− 0.277	0.113	− 0.168	0.344
		Neutrophil	− 0.115	0.516	− 0.063	0.725
		Monocyte	0.511	0.002	− 0.188	0.288
Surface area change	Yu et al. (2018) [31]	Antipsychotics	0.367	0.033	0.163	0.356
	Nalls et al. (2011) [29]	Leukocyte	0.110	0.536	0.127	0.474
		Neutrophil	0.134	0.449	− 0.141	0.425
		Basophil	− 0.109	0.538	− 0.174	0.326
		Monocyte	0.007	0.970	0.240	0.172
		Lymphocytes	0.357	0.038	0.454	0.007
	Keller et al. (2014) [30]	Leukocyte	0.153	0.387	0.500	0.003
		Neutrophil	− 0.126	0.476	0.343	0.047
		Monocyte	0.095	0.594	0.173	0.328

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