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Fig. 1 | BMC Medicine

Fig. 1

From: Metabolic systems approaches update molecular insights of clinical phenotypes and cardiovascular risk in patients with homozygous familial hypercholesterolemia

Fig. 1

Study overview. a Experimental procedure of cross-sectional study. Two independent multi-center cohorts were included in the global metabolomic/lipidomic analyses. Multivariate statistical analysis was used to discover and validate the specific metabolite patterns of HoFH. Regression analysis was employed to investigate the associations of HoFH-related metabolites with typical clinical phenotypes of HoFH patients. b Experimental procedure of follow-up study; 84 HoFH patients with available follow-up information were enrolled from the discovery cohort. Targeted metabolomics and deep proteomics were performed to investigate the ASCVD-associated metabolic network at multi-omic levels. Random forest algorithm was used to select the important metabolic/clinical markers in predicting ASCVD events

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BMC Medicine

ISSN: 1741-7015

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