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Table 2 The PANSS total score change from baseline and reduction rate of PANSS total score after 8-week treatment, stratified by baseline illness severity

From: Early non-response as a predictor of later non-response to antipsychotics in schizophrenia: a randomized trial

 

Olanzapine group

Risperidone group

Amisulpride group

Aripiprazole group

Post-hoc Analysis

Olanzapine vs risperidone

Olanzapine vs amisulpride

Olanzapine vs aripiprazole

Risperidone vs amisulpride

Risperidone vs aripiprazole

Amisulpride vs aripiprazole

All patients

 PANSS total score change from baseline

16.24 ± 11.24

15.70 ± 10.58

16.09 ± 10.42

12.22 ± 9.40

0.588

0.882

 < 0.001

0.694

0.001

 < 0.001

 Reduction rate of PANSS total score (%)

29.0 ± 16.9

29.0 ± 17.2

29.2 ± 17.0

23.7 ± 16.4

0.983

0.877

0.002

0.892

0.002

0.001

Severe schizophrenia (PANSS total score > 95)

 PANSS total score change from baseline

22.64 ± 16.49

25.05 ± 14.32

22.69 ± 12.58

15.69 ± 12.77

0.432

0.987

0.021

0.435

0.003

0.018

 Reduction rate of PANSS total score (%)

29.6 ± 19.6

33.3 ± 18.6

30.9 ± 17.5

19.3 ± 14.9

0.339

0.716

0.006

0.535

 < 0.001

0.002

Moderate schizophrenia (95 ≥ PANSS total score > 75)

 PANSS total score change from baseline

16.48 ± 9.39

14.87 ± 8.84

15.89 ± 9.69

11.84 ± 9.10

0.173

0.618

0.001

0.388

0.030

0.004

 Reduction rate of PANSS total score (%)

30.0 ± 17.2

28.0 ± 17.2

29.6 ± 18.3

23.3 ± 18.4

0.375

0.874

0.013

0.466

0.078

0.018

Mild schizophrenia (75 ≥ PANSS total score > 58)

 PANSS total score change from baseline

10.45 ± 5.39

11.28 ± 6.75

10.43 ± 6.25

10.43 ± 6.25

0.459

0.931

0.986

0.415

0.418

0.940

 Reduction rate of PANSS total score (%)

26.2 ± 13.2

28.2 ± 16.1

26.6 ± 12.8

27.0 ± 14.3

0.437

0.885

0.793

0.539

0.574

0.918

  1. Data are presented as means ± standard deviations
  2. PANSS Positive and Negative Syndrome Scale
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BMC Medicine

ISSN: 1741-7015

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