Table 1 Potential strategies for intercurrent events
From: Why estimands are needed to define treatment effects in clinical trials
Strategy | Relevant values for patients with the intercurrent event |
|---|---|
Treatment policy | Actual values of the variable regardless of whether the intercurrent event has occurred |
Composite | Modified definition of the variable incorporating the intercurrent event |
Hypothetical | Values the variable would have taken in the hypothetical scenario envisaged in which the intercurrent event would not occur |
While on-treatment/at-risk | Values of the variable up to the time of the intercurrent event |
Principal stratum | Restrict population to patients who would not experience the intercurrent event |