Fig. 2

Restricted cubic splines for the associations of biomarkers with mortality. A The restricted cubic spline for the association of NT-proBNP with mortality. B The restricted cubic spline for the association of creatinine with mortality. C The restricted cubic spline for the association of albumin with mortality. D The restricted cubic spline for the association of CRH score with mortality. Adjusted for age, sex, BMI, smoking status, hypertension, hyperlipidemia, diabetes, prior myocardial infarction, cardiomyopathy, atrial fibrillation or flutter, chronic lung disease, NYHA functional class, hemoglobin, LA, LVEDD, LVEF, pulmonary hypertension, severity of VHD, and valvular intervention. The corresponding mortality risks to the median values of biomarkers were chosen as references. NT-proBNP, N-terminal pro-B-type natriuretic peptide; CRH, cardio-renal-hepatic; BMI, body mass index; NYHA, New York Heart Association; LA, left atrial end-diastolic dimension; LVEDD, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; VHD, valvular heart disease; CI, confidence interval