Fig. 2
From: A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth
Rs7889204 likely acts by impacting AGTR2 expression level. A Locus view of rs7889204. Red line indicates the location of the AGTR2 gene on the X chromosome. The diamond in the zoomed view indicates the SNP rs7889204. B Violin plots demonstrating that rs7889204 is an eQTL for AGTR2, with the strongest effect in the uterus. C The rs7889204 locus physically interacts with the promoter region of AGTR2. Chromatin conformation analysis reveals a high distance normalized interaction frequency between the rs7889204 LD block (vertical red var) and the AGTR2 promoter. Higher peaks indicate stronger interactions. Data displayed were obtained from human fibroblasts. Analysis was performed using the 3D Genome Interactive Viewer and Database