Fig. 6
From: A functional mechanism for a non-coding variant near AGTR2 associated with risk for preterm birth
Schematic illustration of rs7889204’s function as an allele-dependent enhancer for AGTR2. The T allele of the non-coding variant rs7889204 results in stronger binding of the CEBPB and HOXA10 transcription factors, with subsequent activation of the target gene AGTR2 in human endometrium stromal fibroblast cells. The C allele disrupts this interaction, resulting in down-regulation of the AGTR2 target gene