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Table 2 Results of the CSH regression model for 10-year incidence of DR (n = 23,531)

From: Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population

Parameter

Crude CSH

(95% CI)

P

Adjusted CSH (95% CI)

P

Sex (M)

1.07 (1.02, 1.12)

 < 0.01**

1.08 (1.03, 1.13)

 < 0.001***

DBP (mmHg)

0.97 (0.94, 1.0)

0.07

0.97 (0.94, 0.99)

 < 0.05*

HbA1c (%)

1.15 (1.11, 1.20)

 < 0.001***

1.15 (1.11, 1.20)

 < 0.001***

HbA1c × NLR#

0.94 (0.91, 0.97)

 < 0.001***

0.94 (0.91, 0.97)

 < 0.001***

SBP (mmHg)

1.05 (1.03, 1.06)

 < 0.001***

1.05 (1.03, 1.06)

 < 0.001***

Age × NLR#

0.99 (0.99, 1.0)

0.30

0.99 (0.99, 0.99)

 < 0.001***

NLR (> 3.04)

2.32 (1.21, 4.43)

 < 0.05*

1.63 (1.28, 2.07)

 < 0.001***

non-HDL-c (mmol/L)

0.82 (0.75, 0.91)

 < 0.001***

0.82 (0.75, 0.91)

 < 0.001***

BMI (kg/m2)

0.95 (0.94, 0.97)

 < 0.001***

0.95 (0.94, 0.97)

 < 0.001***

eGFR (ml/min/1.73 m2)

1.03 (0.98, 1.08)

0.19

-

-

Diabetes drug (yes)

1.11 (1.05, 1.17)

 < 0.001

1.11 (1.06, 1.17)

 < 0.001***

Age (years)

1.02 (0.98, 1.06)

0.17

-

-

eGFR × NLR#

0.98 (0.94, 1.01)

0.26

-

-

  1. Variables labelled with # represent variable interaction terms with NLR (product term represented x symbol between variables). The effect estimates for eGFR, SBP and DBP are presented for a 10-unit increase whereas age and BMI were shown for a 5-unit increase. The same applies to the interaction terms of these variables with NLR in the multivariate regression models
  2. CSH, Cause-specific hazard ratio
  3. *p < 0.05; **p < 0.01; ***p < 0.001