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Table 3 Results of the FGR model for 10-year incidence of DR (n = 23,531)

From: Competing risks analysis for neutrophil to lymphocyte ratio as a predictor of diabetic retinopathy incidence in the Scottish population

Parameter

Crude sHR

(95% CI)

P

Adjusted sHR (95% CI)

P

Sex (M)

1.07 (1.02, 1.12)

 < 0.01**

1.05 (1.01, 1.10)

 < 0.05*

DBP (mm Hg)

0.98 (0.95, 1.01)

0.22

-

-

HbA1c (%)

1.19 (1.15, 1.24)

 < 0.001***

1.19 (1.15, 1.24)

 < 0.001***

HbA1c × NLR#

0.93 (0.90, 0.96)

 < 0.001***

0.94 (0.90, 0.96)

 < 0.001***

SBP (mmHg)

1.00 (1.00, 1.01)

 < 0.001***

1.08 (1.06, 1.09)

 < 0.001***

Age × NLR#

0.97 (0.94, 1.00)

0.05

0.98 (0.97, 0.98)

 < 0.001***

NLR (> 3.04)

2.41 (1.27, 4.57)

 < 0.01

2.24 (1.70, 2.94)

 < 0.001***

non-HDL-c (mmol/L)

1.04 (0.95, 1.15)

0.35

-

-

BMI (kg/m2)

0.99 (0.99, 0.99)

 < 0.001***

0.93 (0.91, 0.94)

 < 0.001***

eGFR (ml/min/1.73 m2)

0.96 (0.92, 1.01)

0.16

0.97 (0.95, 0.98)

 < 0.001***

Diabetes drug (yes)

1.01 (0.97, 1.07)

0.45

-

-

Age (years)

1.01 (0.97, 1.04)

0.60

-

-

eGFR × NLR#

1.00 (0.97, 1.04)

0.80

-

-

  1. Variables labelled with # represent variable interaction terms with NLR. The effect estimates for eGFR, SBP and DBP are presented for a 10-unit increase whereas age and BMI were shown for a 5-unit increase. The same applies to the interaction terms of these variables with NLR in the multivariate regression models (product term represented by × symbol between variables)
  2. sHR, sub hazard ratio
  3. *p < 0.05; **p < 0.01; ***p < 0.001