Fig. 7

Restoring TMIGD1 and BANF1 alleviates inflammation and resumes intestinal barrier function. A, B Body weight and colon length. The arrowhead indicates the time point at which ADV was intraperitoneally injected to boost TMIGD1 and BANF1 expression in mice. Every group, n=5. C Representative images of colons. D Histological scores. Every group, n=5. E Representative colonic HE images. Scale bars, 200 μm. F The concentration of serum FD4. Every group, n=5. G Representative images of ZO-1-stained colon sections. Scale bars, 100 μm. H Measurement of microvilli length (up) and AJC gaps (down) in colonic epithelial cells using TEM. Every group, n=3. I Representative TEM images of the colonic mucosa. The arrowheads indicate AJC. Scale bars, 500 nm. J MPO activity in colon tissues. Every group, n=5. K Serum TNF-α and IL-6 concentrations were detected using multiELISA; Every group, n=5. Data are expressed as mean ± SEM. * p<0.05, ** p<0.01, *** p<0.001