From: Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study
Outcome | All | Severe malaria with vital organ dysfunction | Severe malaria with hyperparasitaemia only | Severe malaria with severe anaemia only |
---|---|---|---|---|
Delivery outcomes assessed | 83% (97/117) | 91% (30/33) | 84% (41/49) | 74% (26/35) |
Foetal lossa | 23% (25/117) | 51% (16/33) | 13% (6/49) | 9% (3/35) |
Miscarriage (< 28 weeks)a | 16% (10/65) | 29% (4/14) | 14% (4/28) | 9% (2/23) |
Stillbirth (≥ 28 weeks)a | 16% (15/99) | 44% (12/28) | 5% (2/42) | 4% (1/29) |
Day to foetal loss | - | 1 [0–3] | 0, 0, 1, 3, 3, 54 | 23, 30, 90 |
Live-born | 72 | 14 | 35 | 23 |
Estimated gestational age at delivery | 39.3 [38.1–40.2] | 39.4 [38.0–39.5] | 39.5 [38.1–40.1] | 39.2 [37.5–40.4] |
Preterm delivery (< 37 weeks)b | 15% (10/68) | 15% (2/13) | 16% (5/32) | 13% (3/23) |
Sex (boy) | 53% (38/72) | 50% (7/14) | 51% (18/35)) | 56% (13/23) |
Congenital abnormality | 1/72 | 0/14 | 1/35 | 0/23 |
Birthweightc | 2700 [2345–3000] (n = 60) | 2530 [2050–2970] (n = 12) | 2745 [2510–3075] (n = 32) | 2550 [2335–3000] (n = 16) |
SGAc | 38% (23/60) | 58% (7/12) | 31% (10/32) | 38% (6/16) |
Z-scorec | − 1.1 [− 1.7 to − 0.57] (n = 60) | − 1.3 [− 2.1 to − 0.71] (n = 12) | − 0.91 [− 1.5 to − 0.21] (n = 32) | − 1.2 [− 1.9 to − 0.62] (n = 16) |
LBW (< 2500 g)c | 30% (18/60) | 42% (5/12) | 19% (6/32) | 44% (7/16) |