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Table 4 Summary of the maternal and foetal outcomes at the Shoklo Malaria Research Unit (SMRU) on the Thailand-Myanmar border

From: Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study

 Outcome

All

Severe malaria with vital organ dysfunction

Severe malaria with hyperparasitaemia only

Severe malaria with severe anaemia only

Delivery outcomes assessed

83% (97/117)

91% (30/33)

84% (41/49)

74% (26/35)

Foetal lossa

23% (25/117)

51% (16/33)

13% (6/49)

9% (3/35)

 Miscarriage (< 28 weeks)a

16% (10/65)

29% (4/14)

14% (4/28)

9% (2/23)

 Stillbirth (≥ 28 weeks)a

16% (15/99)

44% (12/28)

5% (2/42)

4% (1/29)

Day to foetal loss

-

1 [0–3]

0, 0, 1, 3, 3, 54

23, 30, 90

Live-born

72

14

35

23

Estimated gestational age at delivery

39.3 [38.1–40.2]

39.4 [38.0–39.5]

39.5 [38.1–40.1]

39.2 [37.5–40.4]

Preterm delivery (< 37 weeks)b

15% (10/68)

15% (2/13)

16% (5/32)

13% (3/23)

Sex (boy)

53% (38/72)

50% (7/14)

51% (18/35))

56% (13/23)

Congenital abnormality

1/72

0/14

1/35

0/23

Birthweightc

2700 [2345–3000] (n = 60)

2530 [2050–2970] (n = 12)

2745 [2510–3075] (n = 32)

2550 [2335–3000] (n = 16)

SGAc

38% (23/60)

58% (7/12)

31% (10/32)

38% (6/16)

Z-scorec

 − 1.1 [− 1.7 to − 0.57] (n = 60)

 − 1.3 [− 2.1 to − 0.71] (n = 12)

 − 0.91 [− 1.5 to − 0.21] (n = 32)

 − 1.2 [− 1.9 to − 0.62] (n = 16)

LBW (< 2500 g)c

30% (18/60)

42% (5/12)

19% (6/32)

44% (7/16)

  1. LBW low birth weight, SGA small-for-gestational-age
  2. Median [interquartile range] or percentage (number of outcome / number evaluated) are presented. Postpartum episodes were excluded from this table. Only the last episodes were included from those who had multiple episodes. INTERBROWTH-21st international standard growth chart was used for SGA (defined as < 10%) and Z-score of birthweight for gestational age
  3. aEstimated by Kaplan–Meier method. Miscarriage includes women who had severe malaria before 28 weeks, and stillbirth includes women who were followed up beyond 28 weeks
  4. bFour women who had severe malaria on or after the 37th gestational week were excluded
  5. cOnly live-born singletons without congenital abnormality included. Birthweights weighed > 14 days after delivery were excluded