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Table 1 Assumed M72/AS01E and BCG-revaccination scenarios

From: New tuberculosis vaccines in India: modelling the potential health and economic impacts of adolescent/adult vaccination with M72/AS01E and BCG-revaccination

 

M72/AS01E

BCG-revaccination

Characteristic

Basecase

Varied in univariate

Basecase

Varied in univariate

Policy scenarios

 Age targeting

Routine age 15, campaign for ages 16–34

Older ages (campaign for ages 18–55)

Elderly ages (routine age 60, campaign for ages 61 +)

Routine age 10, campaign for ages 11–18

Older ages (routine age 15, campaign for ages 16–34)

Elderly ages (routine age 60, campaign for ages 61 +)

Vaccine characteristic and coverage scenarios

 Vaccine efficacy

50%

60%

70%

45%

70%

 Duration of protection

10 years

5 years

15 years

20 years

10 years

5 years

15 years

20 years

 Host infection status

AI

CI

NCI

AI

 Mechanism of effect

Prevention of disease

Prevention of infection and disease

Prevention of infection

Prevention of infection and disease

 Introduction year (years of any repeat campaigns)

2030 (2040)

2036 (2046)

2025 (2035, 2045)

2031 (2041)

 Achieved vaccine coverage

Routine = 80%, campaign = 70%

Routine = 70%, campaign = 50%

Routine = 90%, campaign = 90%

Routine and campaign = 80%

Routine and campaign = 70%

Routine and campaign = 90%

  1. Abbreviations: AI Any infection; CI Current infection; NCI No current infection
  2. See Additional file 1 Sect. 4 for full details and references