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Fig. 4 | BMC Medicine

Fig. 4

From: Current coffee consumption is associated with decreased striatal dopamine transporter availability in Parkinson’s disease patients and healthy controls

Fig. 4

A proposed possible mechanism underlying the favorable implication of caffeine to PD pathologies. Caffeine enhances dopamine levels with a secondary reduced DAT availability in current coffee consumers compared to former/never coffee consumers in HC (a) and PD patients (b). The degeneration of dopaminergic neurons results in reduced DAT density and dopamine levels in PD patients (b) compared to HC (a). The inverse alteration of dopamine levels caused by PD pathologies and caffeine may be the reason for the favorable implication of caffeine to PD pathologies

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BMC Medicine

ISSN: 1741-7015

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