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Fig. 5 | BMC Medicine

Fig. 5

From: Tryptophan metabolite norharman secreted by cultivated Lactobacillus attenuates acute pancreatitis as an antagonist of histone deacetylases

Fig. 5

Norharman restored the disruption of lipid rafts and lipid metabolism after Rftn1 knockdown. A Norharman alleviated the structural disruption of lipid rafts induced by Rftn1 knockdown by laser confocal microscopy (1000 ×). B Alterations in lipid-related genes by qPCR (n = 5). C The lipidomic heatmap (n = 5). D The levels of sphingomyelin (SM) and phosphatidylcholine (PC) were validated in vitro by using commercial kits (n = 4). Data are presented as the mean ± SEM; *P < 0.05 and **P < 0.01 vs. the NC group; #P < 0.05 and ##P < 0.01 vs. the siRftn1 or shRftn1 group

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BMC Medicine

ISSN: 1741-7015

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