Fig. 6

Norharman restrained the polarization of M1 macrophages by inhibiting multiple proinflammatory responses. A Heatmap of RNA-seq and KEGG enrichment analyses showed that multiple inflammatory pathways were activated in shRftn1 group (n = 4). B Heatmap of RNA-seq and KEGG enrichment analyses showed that multiple inflammatory pathways were inhibited in the shRftn1 + Nor group (n = 4). C Validation of inflammation-related genes in vitro by qPCR (n = 4). Data are presented as the mean ± SEM; *P < 0.05 and **P < 0.01 vs. the NC group; ^#P < 0.05 and ^##P < 0.01 vs. the shRftn1 group