Table 2 Treatment-emergent adverse events
|  | Patients (n = 100) | ||
|---|---|---|---|
Grades 1–2 | Grade 3 | Grade 4 | |
Any event | 44 (44.0) | 53 (53.0) | 3 (3.0) |
Diarrhea | 72 (72.0) | 24 (24.0) | 0 |
Anemia | 52 (52.0) | 4 (4.0) | 0 |
Palmar-plantar erythrodysesthesia syndrome | 46 (46.0) | 9 (9.0) | 0 |
White blood cell decreased | 52 (52.0) | 2 (2.0) | 1 (1.0) |
Neutrophil count decreased | 35 (35.0) | 7 (7.0) | 1 (1.0) |
Vomiting | 37 (37.0) | 2 (2.0) | 0 |
Blood bilirubin increased | 37 (37.0) | 1 (1.0) | 0 |
Creatinine increased | 37 (37.0) | 1 (1.0) | 0 |
Aspartate aminotransferase increased | 32 (32.0) | 3 (3.0) | 0 |
Alanine aminotransferase increased | 31 (31.0) | 3 (3.0) | 0 |
Weight loss | 34 (34.0) | 0 | 0 |
Anorexia | 27 (27.0) | 5 (5.0) | 0 |
Proteinuria | 32 (32.0) | 0 | 0 |
Hyperuricemia | 31 (31.0) | 0 | 0 |
Nausea | 30 (30.0) | 1 (1.0) | 0 |
Urinary tract infection | 29 (29.0) | 0 | 0 |
Hypokalemia | 21 (21.0) | 5 (5.0) | 1 (1.0) |
Hypertriglyceridemia | 23 (23.0) | 0 | 1 (1.0) |
Hematuria | 19 (19.0) | 0 | 0 |
Hypocalcemia | 19 (19.0) | 0 | 0 |
Stomatitis | 19 (19.0) | 0 | 0 |
Fatigue | 17 (17.0) | 0 | 0 |
Hypophosphatemia | 16 (16.0) | 1 (1.0) | 0 |
Alkaline phosphatase increased | 15 (15.0) | 0 | 0 |
Hypoalbuminemia | 14 (14.0) | 0 | 0 |
Cardiac disorders | 13 (13.0) | 0 | 0 |
Platelet count decreased | 12 (12.0) | 1 (1.0) | 0 |
Hypomagnesemia | 12 (12.0) | 0 | 0 |
Hyperglycemia | 10 (10.0) | 1 (1.0) | 0 |
Sinus tachycardia | 10 (10.0) | 0 | 0 |
Upper respiratory tract infection | 6 (6.0) | 1 (1.0) | 0 |
Rash | 5 (5.0) | 1 (1.0) | 0 |
Gamma-glutamyltransferase increased | 2 (2.0) | 1 (1.0) | 0 |
Lymphocyte count decreased | 2 (2.0) | 1 (1.0) | 0 |
Fever | 1 (1.0) | 1 (1.0) | 0 |
Pneumonitis | 1 (1.0) | 1 (1.0) | 0 |
Blood chloride decreased | 0 | 1 (1.0) | 0 |
Electrocardiogram QT corrected interval prolonged | 0 | 1 (1.0) | 0 |
Fracture | 0 | 1 (1.0) | 0 |
Hypertension | 0 | 1 (1.0) | 0 |
Hyponatremia | 0 | 1 (1.0) | 0 |
Pericardial effusion | 0 | 0 | 1 (1.0) |
Pleural effusion | 0 | 1 (1.0) | 0 |
Thrombosis | 0 | 1 (1.0) | 0 |