Fig. 1

Flowchart of development and validation of the TSC-PROM, according to the standards from the COSMIN. ASEBA, Achenbach System of Empirically Based Assessment; ASR, Adult Self Report; CBCL, Child Behavior Checklist; ICF, International Classification of Functioning and Disability; PROM, patient-reported outcome measure; SF-36, Short-Form 36; TAND, TSC-associated neuropsychiatric disorders