Table 2 Incidence of cardiovascular disease (CVD) and hazard ratios for associations of adverse childhood experiences (ACEs) and adverse adulthood experiences (AAEs) with incident CVD

Cardiovascular disease

 ACEs indicators^a (1-unit per increasing)

NA

NA

1.12 (1.09–1.14)

1.14 (1.11–1.17)

1.12 (1.05–1.20)

1.11 (1.08–1.14)

  No. of ACEs indicators

   0

109

24.41

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   1

272

33.14

1.24 (1.13–1.35)

1.27 (1.16–1.39)

1.29 (1.17–1.42)

1.29 (1.17–1.42)

   2

204

37.78

1.37 (1.25–1.51)

1.45 (1.32–1.60)

1.39 (1.25–1.54)

1.39 (1.25–1.54)

   3

137

42.91

1.54 (1.39–1.71)

1.64 (1.48–1.82)

1.56 (1.39–1.74)

1.56 (1.40–1.75)

    ≥ 4

67

43.93

1.55 (1.37–1.76)

1.70 (1.50–1.93)

1.57 (1.37–1.80)

1.58 (1.38–1.81)

 AAEs indicators^a (1-unit per increasing)

NA

NA

1.21 (1.18–1.24)

1.22 (1.19–1.25)

1.18 (1.15–1.22)

1.19 (1.16–1.22)

  No. of AAEs indicators

   0

427

29.31

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   1

163

36.57

1.11 (1.03–1.19)

1.16 (1.07–1.25)

1.10 (1.01–1.19)

1.10 (1.01–1.19)

   2

96

48.07

1.48 (1.35–1.62)

1.52 (1.38–1.66)

1.42 (1.29–1.56)

1.42 (1.29–1.56)

   3

74

57.19

1.90 (1.71–2.10)

1.94 (1.75–2.15)

1.66 (1.49–1.85)

1.67 (1.50–1.86)

    ≥ 4

29

60.80

2.00 (1.71–2.33)

2.07 (1.77–2.42)

1.99 (1.70–2.34)

2.00 (1.70–2.35)

Heart disease

 ACEs indicators^a (1-unit per increasing)

NA

NA

1.08 (1.04–1.11)

1.10 (1.06–1.14)

1.06 (1.02–1.10)

1.06 (1.02–1.10)

  No. of ACEs indicators

   0

62

13.88

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   1

156

19.01

1.25 (1.10–1.43)

1.30 (1.14–1.48)

1.33 (1.15–1.54)

1.33 (1.15–1.54)

   2

129

23.89

1.24 (1.08–1.43)

1.31 (1.14–1.51)

1.25 (1.07–1.46)

1.25 (1.07–1.46)

   3

85

26.62

1.39 (1.20–1.62)

1.49 (1.28–1.74)

1.42 (1.20–1.68)

1.42 (1.20–1.67)

    ≥ 4

43

28.20

1.41 (1.17–1.70)

1.55 (1.29–1.87)

1.37 (1.12–1.68)

1.37 (1.12–1.68)

 AAEs indicators^a (1-unit per increasing)

NA

NA

1.23 (1.19–1.28)

1.24 (1.20–1.29)

1.19 (1.15–1.24)

1.19 (1.15–1.24)

  No. of AAEs indicators

   0

265

18.19

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   1

96

21.54

1.20 (1.08–1.34)

1.25 (1.12–1.40)

1.17 (1.04–1.32)

1.17 (1.04–1.32)

   2

53

26.54

1.60 (1.40–1.82)

1.63 (1.43–1.86)

1.57 (1.36–1.80)

1.57 (1.36–1.80)

   3

42

32.46

1.91 (1.65–2.22)

1.96 (1.69–2.28)

1.55 (1.32–1.83)

1.55 (1.31–1.83)

    ≥ 4

19

39.83

2.13 (1.71–2.66)

2.19 (1.75–2.74)

2.04 (1.61–2.59)

2.04 (1.61–2.58)

Stroke

 ACEs indicators^a (1-unit per increasing)

NA

NA

1.16 (1.13–1.19)

1.18 (1.15–1.22)

1.16 (1.13–1.20)

1.17 (1.13–1.20)

  No. of ACEs indicators

   0

52

11.86

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   1

135

16.83

1.27 (1.13–1.44)

1.31 (1.16–1.48)

1.32 (1.16–1.50)

1.32 (1.16–1.50)

   2

91

17.26

1.56 (1.38–1.77)

1.66 (1.46–1.89)

1.60 (1.40–1.83)

1.60 (1.40–1.83)

   3

61

19.70

1.72 (1.50–1.97)

1.84 (1.60–2.11)

1.76 (1.52–2.04)

1.76 (1.53–2.04)

    ≥ 4

30

20.30

1.79 (1.53–2.10)

1.98 (1.68–2.33)

1.86 (1.57–2.21)

1.87 (1.58–2.22)

 AAEs indicators^a (1-unit per increasing)

NA

NA

1.19 (1.15–1.23)

1.20 (1.16–1.24)

1.17 (1.13–1.21)

1.17 (1.13–1.21)

  No. of AAEs indicators

   0

192

13.45

1.00 (reference)

1.00 (reference)

1.00 (reference)

1.00 (reference)

   1

81

18.59

1.06 (0.97–1.17)

1.12 (1.01–1.23)

1.06 (0.95–1.17)

1.06 (0.95–1.17)

   2

48

24.64

1.34 (1.18–1.51)

1.37 (1.21–1.55)

1.25 (1.10–1.42)

1.25 (1.10–1.42)

   3

34

27.35

1.74 (1.53–1.99)

1.79 (1.57–2.05)

1.62 (1.41–1.87)

1.63 (1.42–1.88)

    ≥ 4

14

30.70

2.11 (1.74–2.55)

2.22 (1.83–2.69)

2.17 (1.78–2.64)

2.17 (1.78–2.65)