Table 3 Associations of adverse childhood experiences (ACEs) with incident cardiovascular disease (CVD) and mediation proportion of the associations attributed to adverse adulthood experiences (AAEs)

Cardiovascular disease

 ACEs indicators^b (1-unit per increasing)

1.11 (1.08–1.14)

1.09 (1.03–1.16)

17.7 (8.2–34.2)

  No. of ACEs indicators

   0

1.00 (reference)

1.00 (reference)

-

    ≥ 1

1.38 (1.12–1.70)

1.36 (1.10–1.68)

4.6 (1.3–15.4)

Heart disease

 ACEs indicators^b (1-unit per increasing)

1.06 (1.02–1.10)

1.04 (0.98–1.08)

36.7 (4.0–89.0)

  No. of ACEs indicators

   0

1.00 (reference)

1.00 (reference)

-

    ≥ 1

1.32 (1.16–1.51)

1.30 (1.14–1.49)

5.6 (1.0–26.1)

Stroke

 ACEs indicators^b (1-unit per increasing)

1.17 (1.13–1.20)

1.15 (1.11–1.18)

10.9 (4.5–24.0)

  No. of ACEs indicators

   0

1.00 (reference)

1.00 (reference)

-

    ≥ 1

1.51 (1.34–1.70)

1.49 (1.32–1.68)

3.3 (0.9–11.9)