Fig. 5

Validation of the three main PBA-related genes in male placenta samples from MABC study and ROC curves of three prediction models for neurodevelopment in MLPT children from MABC study. a–c For male neurodevelopment delay at 6 months, APOE and CST3 mRNA expression are significantly increased in MLPTs. a Gross-motor domain; b fine-motor domain; c personal-social domain. d–f ROC curves of prediction model using random forest. d Gross-motor domain; e fine-motor domain; f personal-social domain. Base model: birth weight + gestational age at delivery + maternal age + monthly income family capita + pre-pregnancy BMI, mixed model: APOE + CST3 + base model. g–i ROC curves of prediction model using logistic regression. g Gross-motor domain; h fine-motor domain; i personal-social domain. Base model: birth weight + gestational age at delivery + maternal age + monthly income family capita + pre-pregnancy BMI, mixed model: APOE + CST3 + base model. j–l ROC curves of prediction model using decision tree. j Gross-motor domain; k fine-motor domain; l personal-social domain. Base model: birth weight + gestational age at delivery + maternal age + monthly income family capita + pre-pregnancy BMI, mixed model: APOE + CST3 + base model