Fig. 2

Salivary sEVs concentrations in age-matched healthy controls and PD patients. A Salivary sEV levels (particle/ml) from healthy controls (HC) and PD patients in scatter mode NTA (p = 0.0001) and its ROC curve analysis (B). C Fluorescence-dye-labeled salivary sEV levels (particle/ml) from HC and PD patients in fluorescence mode NTA (p = 0.0001) and its ROC curve analysis (D). E CD63 protein-specific salivary sEV levels (particle/ml) from HC and PD patients in antibody mode NTA (p = 0.0006) and its ROC curve analysis (F). G Alpha-synuclein protein levels (pg/ml) in the salivary sEV from HC and PD patients (0.004) by ELISA and its ROC curve analysis (H). All graphs are presented with mean ± SEM