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Table 1 Baseline characteristics

From: A phase 1 trial of fuzuloparib in combination with apatinib for advanced ovarian and triple-negative breast cancer: efficacy, safety, pharmacokinetics and germline BRCA mutation analysis

 

Ovarian cancer (n = 30)

Triple-negative breast cancer (n = 22)

Age, years

54.5 (44–70)

53 (22–66)

ECOG performance status

 0

19 (63.3%)

18 (81.8%)

 1

11 (36.7%)

4 (18.2%)

Histology type

 High-grade serous

30 (100%)

-

No. of lines of previous palliative chemotherapy

 2

21 (70.0%)

22 (100%)

 3

7 (23.3%)

0

 4

2 (6.7%)

0

Invasive metastasis

 Yes

12 (40.0%)

13 (59.1%)

 No

18 (60.0%)

9 (40.9%)

No. of metastasis sites

 1

4 (13.3%)

7 (31.8%)

 2

14 (46.7%)

12 (54.6%)

 3

6 (20.0%)

3 (13.6%)

  ≥ 4

6 (20.0%)

0

CA-125

  < ULN

4 (13.3%)

-

  ≥ ULN- < 2ULN

3 (10.0%)

-

  ≥ 2ULN

22 (73.3%)

-

BRCA mutation status

 Mutation carrier

8 (26.7%)

3 (13.6%)

 Wild-type

22 (73.3%)

19 (86.4%)

Platinum status

 Sensitive

10 (33.3%)

-

 Resistant

17 (56.7%)

-

 Refractory

3 (10.0%)

-

  1. Data are n (%) or median (range). ECOG Eastern Cooperative Oncology Group, ULN Upper limit of normal