Triangulating evidence from observational and Mendelian randomization studies of ketone bodies for cognitive performance

Table 1 SNPs associated with 3-β-hydroxybutyrate under GWAS significance thresholds at P < 5 × 10⁻⁸

SNPs	Chr	Closest reference gene^a	Beta coefficient	SE	P-value (discovery stage)	Effect allele	Effect allele frequency
Association with P < 5 × 10⁻⁸
rs9302635	16	DHX38	− 0.083	0.009	6.59 × 10⁻²¹	T	0.820
rs9987289	8	PPP1R3B	− 0.084	0.011	3.42 × 10⁻¹⁴	A	0.105
rs1508816	5	(OXCT1)	0.052	0.008	5.04 × 10⁻¹¹	T	0.745
rs2419604	10	GPAM	− 0.050	0.008	4.27 × 10⁻¹⁰	A	0.287
rs6982502	8	(TRIB1)	0.041	0.007	2.25 × 10⁻⁸	T	0.540

Sample size = 45,031
Chr Chromosome, SE Standard error
^aGenes for SNPs that are outside the transcript boundary of the protein-coding gene are shown in parentheses [e.g., (OXCT1)]

ISSN: 1741-7015