Table 3 Instrument strength of each replication trait of interest. N sample size, nSNPs number of SNPs at genome-wide significance (p < 5 × 10−8) after LD clumping
Trait | N | nSNPs | R2 | F statistic |
|---|---|---|---|---|
Childhood body mass index (from EGG) | 39,618 | 16 | 0.0236 | 59.89 |
Adulthood body mass index (from GIANT) | 171,970 | 37 | 0.0145 | 68.25 |
Age at menarche (from ReproGen) | 182,416 | 60 | 0.0261 | 81.52 |
Age at menopause (from ReproGen) | 69,360 | 39 | 0.0420 | 77.89 |
Age at first birth (from SSGAC) | 189,656 | 5 | 9.14 × 10−4 | 34.70 |