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Table 1 Criteria to determine the treating physician’s diagnosis

From: Diagnostic and societal impact of implementing the syncope guidelines of the European Society of Cardiology (SYNERGY study)

Treating physician’s conclusion

Criteria to evaluate concordance of the management plan with the suggested condition

Admission

Follow-up

Investigations following ED visit

Treatment

Reflex syncope (including vasovagal syncope, carotid sinus syndrome and situational syncope)

No admission except for underlying cause (e.g. gastroenteritis) or trauma due to syncope

No referral to outpatient clinic, except for syncope unit

No investigations except for tilt test (optional)

Optional:

Education in counter pressure manoeuvres

Treatment with drugs that may prevent reflex syncope (e.g. midodrine)

Orthostatic hypotension (including initial, classic and delayed orthostatic hypotension)

No admission except for underlying cause (e.g. dehydration, bleeding)

Optional:

Referral to GP or outpatient clinic for analysis of underlying cause

Optional:

Tilt table testing, active standing test, autonomic function test, work-up to identify underlying neurological cause (e.g. polyneuropathy)

Optional:

Treatment of underlying cause (e.g. rehydration)

Deprescribing of blood pressure-lowering drugs

Prescription of blood pressure-increasing drugs

Education in counter-pressure manoeuvres

Cardiac syncope

Cardiopulmonary and great vessels

Admission to cardiology department* except when treatment did not necessitate admission

Admission if needed

Follow-up cardiology department to confirm diagnosis or evaluate treatment

Follow-up pulmonologist, vascular surgeon

Optional:

Monitoring heart rhythm (in-hospital, Holter ECG)

Echocardiography

Exercise testing

Implantation of cardiac monitoring devices

Imaging aorta/pulmonary veins

Optional:

Implantation of pacemaker/defibrillator

Surgical intervention for structural causes

Prescription of anti-arrhythmical drugs

Optional:

Anti-thrombotic therapy

Surgical intervention

Epileptic seizure

Optional:

Admission to neurology department

Referral to neurology outpatient clinic except for provoked seizures

Optional:

MRI, CT brain or

EEG

Optional:

Prescription of anti-seizure medication

Psychogenic TLOC

No admission except for injuries due to TLOC necessitating admission

Variable (no follow-up, referral to GP, consultation psychiatrist or psychologist)

None

Education or treatment plan as defined by psychiatrist, psychologist or GP

  1. The classification of the treating physician’s diagnosis was based on the final conclusion in the medical notes and the chosen diagnostic or therapeutic pathway. Concordance between the presumed diagnosis and the management plan was evaluated using predefined criteria for all causes of TLOC. If the treating physician’s conclusion was concordant with the management plan, then this diagnosis was labelled as the treating physician’s diagnosis. If the diagnosis was not concordant with the management plan, we classified the treating physician’s diagnosis as unexplained syncope or TLOC
  2. Abbreviations: GP General practitioner, OH Orthostatic hypotension, CT Computed tomography, MRI Magnetic resonance imaging, EEG Electroencephalogram, TLOC Transient loss of consciousness
  3. *Or another department with facilities to continuously monitor heart rate