Fig. 5

Effect of CER-001 on ApoA-I level, LPS removal, and inflammatory response in the pilot study RACERS. A–I Serum levels of ApoA-I, LPS, IL-6, IL-8, MCP1, TNF-α, sTREM-1, VCAM, and ICAM were measured using ELISA kits. Data for panels A2–I are represented as changes from baseline (day 1 pre-dose) values. Treatment differences were assessed by using a mixed model ANOVA for values on days 3, 6, and 9 with a significance level of α = 0.05; significant pairwise comparisons are shown. No adjustments were made for multiple comparisons. Abbreviations: ApoA-I apolipoprotein A-I; ICAM endothelial intercellular adhesion molecule; IL-6 interleukin 6; IL-8 interleukin 8; IL-10 interleukin 10; LPS lipopolysaccharides; MCP-1 monocyte chemoattractant protein-1; TNF-α tumor necrosis factor α; sTREM-1 soluble triggering receptor expressed on myeloid cells 1; VCAM vascular cell adhesion molecule