Fig. 4

Cross-trait meta-analysis between gallstone disease and cardiovascular diseases. In each circular Manhattan plot, the outermost circle shows the cross-trait meta-analysis results between (A) gallstone disease and stroke and (B) gallstone disease and coronary artery disease; from the periphery to the center, each circle shows the GWAS results on gallstone disease and cardiovascular diseases, respectively. Light blue indicates variants with genome-wide significance (P < 5 × 10^–8) while dark blue indicates variants with P ≥ 5 × 10^–8. According to their single-trait and cross-trait characteristics, SNPs are divided into two different types named “Known associated SNP” and “Novel shared SNP”,which are presented in grey and red, respectively. RSIDs of them are listed. The bar plot presents the numbers of two types of SNPs detected in the cross-trait meta-analysis between (C) gallstone disease and stroke and (D) gallstone disease and coronary artery disease