Fig. 1

Scores and impact factor of successful and stalled breast and colorectal cancer BM publications. A) Bar chart indicating the total average scores between successful. (n=105) and stalled Biomarkers (n=80). B) Bar chart showing the individual average scores in CV, AV and CU categories. C) Bar chart indicating the total average scores between successful (n=132) and stalled CRC Biomarkers (n=123). D) Bar chart showing the individual average scores in CV, AV and CU categories. Asterisks denote the level of significance where ns: P > 0.05 *: P≤ 0.05, **: P ≤0.01, ***: P ≤0.001, ****: P ≤0.0001. All of the evaluated publications were independently scored by two assessors (BC: 50% of the journals by SM and 50% by MS; CRC 50% IP and 50% MK) as a validation of toolkit scoring strategy, with less than 12% difference between original and reviewer 1 and 2 scores, suggesting low inter-rater variability. AV, analytical validity; CV, clinical utility; CU, clinical utility; BM, biomarkers; CRC, colorectal cancer; BC, breast cancer