Fig. 8

NINJ1-neutralization antibody limited TAD formation. A Workflow for NINJ1-neutralization antibody treatment experiments. B Ultrasonographic examination of the thoracic aorta mean diameter in each group of surviving mice after 3 weeks (n = 6, 10, 11, and 8, respectively). C Representative photographs of aortas in each group. D The incidence and mortality of TAD in each group at the end time of the experiment. E Representative H&E, Masson, and EVG staining of the mouse thoracic aortas in each group. Arrows indicate the elastin disruption. F Quantitative analysis of thoracic aortic fibrosis area in each group (n = 6, 7, 10, and 6, respectively). G Grade of the elastin degradation in the aortic wall (n = 6, 7, 10, and 6, respectively). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001; quantitative data were shown as mean ± SEM; statistical analysis in B, F, and G was performed with one-way ANOVA with Tukey’s tests, and chi-square test in D, respectively