Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study

Table 1 Summary of genome-wide significant genetic instruments of sleep traits in the discovery genome-wide association studies

Sleep traits	Discovery GWAS	PMID	N	Cohorts used by the discovery GWAS		No. of SNPs identified
Sleep traits	Discovery GWAS	PMID	N	UKBB	23andMe	No. of SNPs identified
Insomnia symptoms	Jansen et al., 2019 [30]	30804565	1 331 010	109 402 cases and 277 131 controls	288 557 cases and 655 920 controls	248
24-hour sleep duration (h)	Dashti et al., 2019 [31]	30846698	446 118	446 118 samples	Not included	78
Short sleep (≤ 6 h vs. 7–8 h)	Dashti et al., 2019 [31]	30846698	411 934	106 192 cases and 305 742 controls	Not included	27
Long sleep (≥ 9 h vs. 7–8 h)	Dashti et al., 2019 [31]	30846698	339 926	34 184 cases and 305 742 controls	Not included	8
Chronotype (morning preference)^*	Jones et al., 2019 [32]	30696823	651 295	252 287 cases and 150 908 controls	120 478 cases and 127 622 controls	351

GWAS indicated genome-wide association studies, N sample size, SNPs single nucleotide polymorphisms, UKBB UK Biobank
^*In the discovery GWAS of chronotype, the chronotype increasing allele is morning preference

ISSN: 1741-7015