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Table 2 Baseline characteristics of study participants who had an episode of acute myocardial infarction (AMI) and not had AMI during follow-up in UK Biobank and HUNT2

From: Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study

 

UK Biobank (N = 332 676)

HUNT2 (N = 44 728)

No AMI diagnosis

AMI diagnosis

No AMI diagnosis

AMI diagnosis

Total, % (n)

97.65 (324 863)

2.35 (7 813)

89.97 (40 240)

10.03 (4 488)

Variables, % (n)

 Male

44.03 (143 029)

70.24 (5 488)

43.87 (17 654)

61.27 (2 750)

  Missing, % (n)

-

-

-

-

 Married

74.19 (241 001)

72.60 (5 672)

61.67 (24 814)

69.43 (3 116)

  Missing, % (n)

0.48 (1 561)

0.93 (73)

0.23 (91)

0.07 (3)

 Weekly alcohol intake

50.55 (164 215)

47.43 (3 706)

22.59 (9 089)

18.72 (840)

  Missing, % (n)

0.05 (161)

0.08 (6)

7.31 (2 943)

9.54 (428)

 Current smokers

9.97 (32 392)

18.17 (1 420)

27.31 (10 991)

32.53 (1 460)

  Missing, % (n)

0.29 (956)

0.37 (29)

1.52 (610)

1.96 (88)

 Highly physically active

33.39 (108 475)

31.95 (2 496)

33.41 (13 443)

22.59 (1 041)

  Missing, % (n)

17.69 (57 463)

19.12 (1 494)

7.33 (2 950)

14.84 (666)

 Tertiary education

43.24 (140 458)

37.71 (2 946)

21.74 (8 747)

11.85 (532)

  Missing, % (n)

0.74 (2 418)

1.15 (90)

3.16 (1 273)

7.20 (323)

 Shift workers

5.17 (16 797)

5.30 (414)

15.91 (6 403)

9.05 (406)

  Missing, % (n)

0.27 (888)

0.22 (17)

7.31 (2 940)

6.66 (299)

 Employed

57.28 (186 073)

43.45 (3 395)

68.66 (27 627)

45.94 (2 062)

  Missing, % (n)

0.24 (773)

0.18 (14)

0.95 (381)

0.62 (28)

 Use of sleep medication(s)

0.97 (3 135)

1.37 (107)

6.10 (2 454)

10.90 (489)

  Missing, % (n)

-

-

9.39 (3 778)

10.90 (489)

 Suffering from depression

12.06 (39 190)

15.10 (1 180)

-

-

  Missing, % (n)

-

-

-

-

 Suffering from anxiety

6.63 (21 543)

10.11 (790)

-

-

  Missing, % (n)

-

-

-

-

 Suffering from chronic illness

30.84 (100 189)

47.13 (3 682)

30.27 (12 182)

48.84 (2 192)

  Missing, % (n)

2.03 (6 600)

2.20 (172)

3.02 (1 215)

4.48 (201)

Variables, mean (SD)

 Age, years

56.82 (7.95)

60.36 (6.82)

47.71 (16.07)

61.12 (13.23)

  Missing, % (n)

-

-

-

-

 TDI

−1.60 (2.91)

−1.22 (3.12)

-

-

  Missing, % (n)

0.12 (386)

0.12 (9)

-

-

 BMI, kg/m2

27.37 (4.75)

28.74 (4.80)

26.18 (4.04)

27.41 (4.03)

  Missing, % (n)

0.31 (993)

0.41 (32)

0.46 (184)

0.87 (39)

 SBP, mmHg

138.20 (18.59)

145.80 (19.18)

135.50 (20.44)

148.80 (22.56)

  Missing, % (n)

0.09 (297)

0.06 (6)

0.11 (43)

0.13 (6)

 Serum cholesterol, mmol/L

5.74 (1.13)

5.70 (1.28)

5.80 (1.23)

6.55 (1.21)

  Missing, % (n)

4.56 (14 819)

4.62 (361)

0.11 (44)

0.11 (5)

 Blood glucose, mmol/L

5.11 (1.17)

5.41 (1.86)

5.36 (1.36)

5.90 (1.96)

  Missing, % (n)

12.73 (41 362)

12.39 (968)

0.15 (61)

0.20 (9)

 HADS – D scores

-

-

3.31 (2.97)

4.01 (3.15)

  Missing, % (n)

-

-

6.38 (2 569)

11.25 (505)

 HADS – A scores

-

-

4.18 (3.25)

4.06 (3.37)

  Missing, % (n)

-

-

13.01 (5 237)

22.08 (991)

  1. AMI indicates acute myocardial infarction, SD standard deviation, TDI Townsend deprivation index, BMI body mass index, SBP systolic blood pressure, HADS – D scores Hospital Anxiety and Depression Scale – Depression scores, HADS – A scores Hospital Anxiety and Depression Scale – Anxiety scores