Fig. 2
Volcano plot showing effects of human plasma proteins on the risk of multiple myeloma. Data are expressed as odds ratios (OR) estimated by the inverse variance-weighted (IVW) method. The red dots represent the plasma proteins was significant positively associated with the risk of multiple myeloma (PFDR < 0.05). The blue dots represent the plasma proteins significant was inversely associated with the risk of multiple myeloma (PFDR < 0.05). The black dashed line represents the association threshold of FDR corrected P-value < 0.05. C1QC, complement C1q subcomponent subunit C; CBR1, carbonyl reductase 1; FCGR3B, Fc-gamma receptor III-B; FSTL1, follistatin-related protein 1; FDR, false discovery rate; GPC1, glypican 1; GZMB, granzyme B; NAMPT, nicotinamide phosphoribosyl transferase; NCF2, neutrophil cytosol factor 2; PAFAH1B2, platelet-activating factor acetyl hydrolase IB subunit beta; PDE4D, cAMP-specific 3',5'-cyclic phosphodiesterase 4D; PTPN4, protein tyrosine phosphatase non-receptor type 4; SOCS3, suppressor of cytokine signaling 3; TIE1, Tyrosine kinase with immunoglobulin-like and EGF-like domains 1; SNP, single nucleotide polymorphism