Table 1 Causal effects of inflammatory bowel disease on 32 site-specific extracolonic cancer risk in UK Biobank

Respiratory system

 Larynx

0.929 (0.789, 1.094)

0.380

0.008

0.006

 Bronchus and lung

1.005 (0.956, 1.055)

0.853

0.029

0.028

Oral cavity and pharynx

 Oral cavity

1.180 (1.059, 1.316)

0.003

0.134

0.137

 Pharynx

1.011 (0.909, 1.125)

0.836

0.724

0.722

Digestive system cancer

 Esophagus

0.960 (0.888, 1.038)

0.303

0.923

0.928

 Small intestine

1.043 (0.888, 1.226)

0.607

0.213

0.193

 Stomach

0.961 (0.880, 1.049)

0.368

0.868

0.872

 Pancreas

1.001 (0.921, 1.087)

0.988

0.221

0.242

 Hepatocellular

0.923 (0.743, 1.148)

0.473

0.406

0.404

 Hepatic bile duct

1.082 (0.849, 1.379)

0.546

0.250

0.271

 Extrahepatic bile duct

0.919 (0.775, 1.090)

0.332

0.496

0.500

Hematologic malignancy

 Multiple myeloma

0.938 (0.851, 1.035)

0.203

0.018

0.019

 Hodgkin lymphoma

0.978 (0.850, 1.126)

0.761

0.423

0.406

 Non-Hodgkin lymphoma

1.029 (0.969, 1.093)

0.343

 < 0.001

0.001

 Acute myelocytic leukemia

0.908 (0.801, 1.029)

0.130

0.195

0.204

 Chronic myeloid leukemia

0.839 (0.696, 1.012)

0.067

0.392

0.425

 Chronic lymphocytic leukemia

1.003 (0.899, 1.120)

0.952

0.002

0.003

Genital system

 Ovary

0.970 (0.903, 1.042)

0.411

0.714

0.700

 Uterine cervix

1.050 (0.900, 1.225)

0.536

0.146

0.168

 Uterine corpus

1.006 (0.938, 1.079)

0.867

0.041

0.032

 Vulva

0.991 (0.801, 1.224)

0.930

0.469

0.468

 Testis

1.028 (0.914, 1.156)

0.644

0.999

0.997

 Prostate

1.008 (0.974, 1.044)

0.651

 < 0.001

 < 0.001

Breast

1.045 (1.005, 1.086)

0.043

0.878

0.901

Skin cancer

 Malignant melanoma

1.004 (0.954, 1.057)

0.871

0.074

0.051

 Malignant nonmelanoma

1.030 (0.995, 1.067)

0.099

 < 0.001

 < 0.001

Other

 Eye and annexa

1.146 (0.968, 1.356)

0.115

0.483

0.478

 Kidney

1.013 (0.947, 1.084)

0.701

0.482

0.478

 Bladder

0.994 (0.944, 1.047)

0.821

0.106

0.098

 Bone

1.025 (0.852, 1.232)

0.794

0.999

0.998

 Brain

1.104 (1.003, 1.216)

0.043

0.336

0.350

 Thyroid

0.976 (0.868, 1.097)

0.683

0.955

0.953