Table 2 Causal effects of Crohn’s disease and ulcerative colitis on 32 site-specific extracolonic cancer risk in UK Biobank

Respiratory system

 Larynx

0.928 (0.799, 1.077)

0.090

0.046

0.051

1.025 (0.861, 1.220)

0.779

0.064

0.062

 Bronchus and lung

0.997 (0.954, 1.042)

0.900

0.012

0.013

1.036 (0.985, 1.090)

0.167

0.270

0.281

Oral cavity and pharynx

 Oral cavity

1.112 (1.008, 1.227)

0.034

0.111

0.135

1.158 (1.041, 1.288)

0.007

0.487

0.455

 Pharynx

1.019 (0.927, 1.121)

0.696

0.847

0.840

1.035 (0.924, 1.159)

0.553

0.371

0.367

Digestive system cancer

 Esophagus

0.982 (0.917, 1.050)

0.589

0.506

0.502

0.986 (0.906, 1.074)

0.752

0.973

0.973

 Small intestine

1.037 (0.892, 1.205)

0.640

0.018

0.015

1.124 (0.949, 1.332)

0.175

0.486

0.490

 Stomach

0.997 (0.924, 1.076)

0.939

0.507

0.488

0.951 (0.864, 1.046)

0.303

0.590

0.591

 Pancreas

0.977 (0.910, 1.047)

0.506

0.360

0.359

1.020 (0.932, 1.116)

0.671

0.272

0.257

 Hepatocellular

0.949 (0.785, 1.147)

0.586

0.387

0.366

0.908 (0.714, 1.155)

0.432

0.289

0.302

 Hepatic bile duct

1.170 (0.948, 1.444)

0.144

0.257

0.285

1.020 (0.792, 1.313)

0.879

0.634

0.668

 Extrahepatic bile duct

0.964 (0.831, 1.118)

0.626

0.687

0.672

0.928 (0.772, 1.116)

0.428

0.792

0.774

Hematologic malignancy

 Multiple myeloma

0.969 (0.894, 1.051)

0.449

0.137

0.141

0.983 (0.885, 1.091)

0.749

0.094

0.102

 Hodgkin lymphoma

0.990 (0.877, 1.117)

0.867

0.669

0.673

0.965 (0.820, 1.136)

0.672

0.154

0.175

 Non-Hodgkin lymphoma

1.010 (0.958, 1.065)

0.709

 < 0.001

 < 0.001

1.058 (0.987, 1.134)

0.110

 < 0.001

 < 0.001

 Acute myelocytic leukemia

0.930 (0.838, 1.032)

0.170

0.524

0.508

0.991 (0.860, 1.142)

0.899

0.115

0.117

 Chronic myeloid leukemia

0.889 (0.757, 1.043)

0.149

0.624

0.633

0.921 (0.747, 1.134)

0.438

0.305

0.307

 Chronic lymphocytic leukemia

0.981 (0.891, 1.080)

0.697

0.004

0.006

0.967 (0.872, 1.073)

0.528

0.793

0.791

Genital system

 Ovary

0.951 (0.892, 1.015)

0.132

0.216

0.211

0.983 (0.909, 1.063)

0.661

0.522

0.511

 Uterine cervix

1.043 (0.920, 1.184)

0.510

0.545

0.546

0.978 (0.834, 1.147)

0.786

0.808

0.807

 Uterine corpus

0.989 (0.928, 1.053)

0.723

0.004

0.005

0.954 (0.885, 1.028)

0.216

0.114

0.105

 Vulva

1.142 (0.947, 1.377)

0.165

0.336

0.351

0.864 (0.673, 1.109)

0.251

0.118

0.124

 Testis

1.040 (0.939, 1.151)

0.451

0.996

0.997

0.983 (0.864, 1.117)

0.790

0.998

0.999

 Prostate

0.998 (0.973, 1.024)

0.902

0.441

0.443

1.012 (0.973, 1.052)

0.543

 < 0.001

0.001

Breast

1.008 (0.958, 1.061)

0.691

0.980

0.961

1.013 (0.955, 1.074)

0.675

0.692

0.697

Skin cancer

 Malignant melanoma

1.024 (0.978, 1.072)

0.305

0.038

0.039

1.009 (0.953, 1.069)

0.749

0.087

0.084

 Malignant nonmelanoma

1.041 (1.009, 1.075)

0.012

 < 0.001

 < 0.001

1.012 (0.985, 1.039)

0.392

 < 0.001

 < 0.001

Other

 Eye and annexa

1.120 (0.978, 1.296)

0.129

0.561

0.564

1.092 (0.908, 1.312)

0.350

0.557

0.556

 Kidney

1.033 (0.975, 1.095)

0.274

0.500

0.510

1.011 (0.937, 1.092)

0.773

0.234

0.250

 Bladder

1.008 (0.965, 1.053)

0.724

0.214

0.211

0.979 (0.925, 1.035)

0.453

0.151

0.160

 Bone

1.062 (0.905, 1.245)

0.460

0.978

0.987

0.900 (0.736, 1.100)

0.304

0.910

0.908

 Brain

1.105 (1.013, 1.205)

0.024

0.124

0.144

1.081 (0.975, 1.198)

0.137

0.490

0.474

 Thyroid

1.005 (0.907, 1.112)

0.930

0.713

0.736

0.958 (0.841, 1.091)

0.514

0.403

0.413