Table 5 Top 40 (of 348) metabolites present at lower abundance in Black relative to White participants at FDR < 0.05 in the most completely adjusted modela,b
From: Plasma metabolomics profiles in Black and White participants of the Adventist Health Study-2 cohort
Metabolite | Fold difference | Subclass | Major class | FDR (Storey) |
|---|---|---|---|---|
n-Methylpipecolate | 0.27 | Bacterial/fungal | Xenobiotics | 4.8E−03 |
n6-methyllysine | 0.31 | Lysine metabolism | Amino acid | 2.4E−03 |
Theobromine | 0.33 | Xanthine metabolism | Xenobiotics | 1.9E−03 |
Tryptophan betaine | 0.35 | Tryptophan metabolism | Amino acid | 1.8E−04 |
Myristoleate (14:1n5) | 0.36 | Long-chain monounsaturated fatty acid | Lipid | 1.2E−03 |
3-Methylxanthine | 0.37 | Xanthine metabolism | Xenobiotics | 2.5E−04 |
Palmitoyl-linoleoyl-glycerol (16:0/18:2) [1] | 0.38 | Diacylglycerol | Lipid | 2.3E−04 |
5-Acetylamino-6-amino-3-methyluracil | 0.39 | Xanthine metabolism | Xenobiotics | 2.7E−03 |
2-Palmitoleoylglycerol (16:1) | 0.40 | Monoacylglycerol | Lipid | 3.0E−04 |
Metabolonic lactone sulfate | 0.41 | Partially characterized | Partially characterized | 4.8E−04 |
Alpha-cehc sulfate | 0.41 | Tocopherol metabolism | Cofactors and vitamins | 5.3E−04 |
Galactonate | 0.42 | Fructose, mannose, and galactose metabolism | Carbohydrate | 4.0E−04 |
2-Hydroxyacetaminophen sulfate | 0.42 | Drug — analgesics, anesthetics | Xenobiotics | 2.9E−02 |
7-Methylxanthine | 0.43 | Xanthine metabolism | Xenobiotics | 1.5E−03 |
1-Palmitoleoylglycerol (16:1) | 0.44 | Monoacylglycerol | Lipid | 2.2E−04 |
Oleoyl-linoleoyl-glycerol (18:1/18:2) [2] | 0.45 | Diacylglycerol | Lipid | 1.2E−03 |
Caffeine | 0.45 | Xanthine metabolism | Xenobiotics | 8.2E−03 |
Linoleoyl-linolenoyl-glycerol (18:2/18:3) [2] | 0.45 | Diacylglycerol | Lipid | 1.6E−04 |
1,7-Dimethylurate | 0.46 | Xanthine metabolism | Xenobiotics | 2.6E−03 |
1-Methylxanthine | 0.47 | Xanthine metabolism | Xenobiotics | 1.2E−03 |
Docosatrienoate (22:3n6) | 0.48 | Long-chain polyunsaturated fatty acid (n3 and n6) | Lipid | 2.1E−04 |
3-Methylglutarylcarnitine (2) | 0.48 | Leucine, isoleucine, and valine metabolism | Amino acid | 4.0E−04 |
Palmitoleate (16:1n7) | 0.49 | Long-chain monounsaturated fatty acid | Lipid | 2.0E−04 |
2-Palmitoleoyl-gpc (16:1) | 0.49 | Lysophospholipid | Lipid | 4.0E−03 |
9-Hydroxystearate | 0.49 | Fatty acid, monohydroxy | Lipid | 8.1E−05 |
Linoleoyl-linoleoyl-glycerol (18:2/18:2) [2] | 0.50 | Diacylglycerol | Lipid | 8.2E−05 |
5alpha-androstan-3beta,17alpha-diol disulfate | 0.50 | Androgenic steroids | Lipid | 1.3E−03 |
Vanillic acid glycine | 0.51 | Food component/plant | Xenobiotics | 9.6E−04 |
3-Aminoisobutyrate | 0.51 | Pyrimidine metabolism, thymine containing | Nucleotide | 4.3E−04 |
Ceramide (d16:1/24:1, d18:1/22:1) | 0.51 | Ceramides | Lipid | 1.9E−04 |
Palmitoloelycholine | 0.52 | Fatty acid metabolism (acyl choline) | Lipid | 2.8E−04 |
2-Aminophenol sulfate | 0.52 | Food component/plant | Xenobiotics | 2.0E−03 |
Oleoyl-linoleoyl-glycerol (18:1/18:2) [1] | 0.53 | Diacylglycerol | Lipid | 1.6E−03 |
1-Palmitoyl-2-palmitoleoyl-gpc (16:0/16:1) | 0.53 | Phosphatidylcholine (PC) | Lipid | 9.6E−04 |
Palmitoyl-linoleoyl-glycerol (16:0/18:2) [2] | 0.53 | Diacylglycerol | Lipid | 2.1E−04 |
n6,n6-dimethyllysine | 0.53 | Lysine metabolism | Amino acid | 8.0E−04 |
Cystathionine | 0.54 | Methionine, cysteine, SAM, and taurine metabolism | Amino acid | 1.4E−03 |
5alpha-androstan-3alpha,17beta-diol monosulfate (1) | 0.54 | Androgenic steroids | Lipid | 4.0E−04 |