Table 6 Metabolite subclasses associated with race (Black vs White) at FDR < 0.05 in the most completely adjusted model^a,b

Creatine metabolism

1.20 (1.11, 1.29)

3

3

3

0

< 9.0E−05

Long-chain monounsaturated fatty acid

0.61 (0.49, 0.75)

7

7

0

7

9.5E−05

Pyrimidine metabolism, thymine containing

0.73 (0.63, 0.83)

2

1

0

1

1.2E−04

Ceramides

0.74 (0.65, 0.85)

9

8

0

8

1.4E−04

Lysophospholipid

0.75 (0.67, 0.84)

29

24

0

24

1.6E−04

Monoacylglycerol

0.65 (0.54, 0.79)

16

13

0

13

1.6E−04

Phosphatidylethanolamine (PE)

0.70 (0.60, 0.83)

12

10

0

10

1.8E−04

Phosphatidylinositol (PI)

0.75 (0.67, 0.83)

6

6

0

6

2.4E−04

Glycerolipid metabolism

0.77 (0.68, 0.87)

2

2

0

2

2.6E−04

Tryptophan metabolism

0.84 (0.77, 0.92)

20

11

0

11

3.3E−04

Diacylglycerol

0.57 (0.47, 0.68)

11

10

0

10

4.7E−04

Pyrimidine metabolism, orotate containing

0.79 (0.70, 0.90)

3

2

0

2

7.1E−04

Long-chain polyunsaturated fatty acid (n3 and n6)

0.72 (0.61, 0.86)

17

14

0

14

7.7E−04

Leucine, isoleucine, and valine metabolism

0.87 (0.80, 0.94)

28

15

0

15

7.8E−04

Lysine metabolism

0.83 (0.75, 0.92)

16

6

0

6

9.5E−04

Fatty acid metabolism (acyl choline)

0.72 (0.60, 0.87)

9

8

0

8

9.8E−04

Xanthine metabolism

0.49 (0.32, 0.74)

13

12

0

12

1.5E−03

Ascorbate and aldarate metabolism

0.84 (0.75, 0.93)

6

5

0

5

2.2E−03

Phosphatidylcholine (PC)

0.85 (0.77, 0.94)

19

10

0

10

2.4E−03

Fatty acid, dihydroxy

0.85 (0.76, 0.94)

5

3

0

3

2.9E−03

Fructose, mannose, and galactose metabolism

0.79 (0.68, 0.92)

4

1

0

1

3.3E−03

Guanidino and acetamido metabolism

0.73 (0.60, 0.89)

2

1

0

1

3.4E−03

Pentose metabolism

0.85 (0.76, 0.95)

6

4

0

4

4.7E−03

Long-chain saturated fatty acid

0.82 (0.72, 0.95)

7

5

0

5

7.0E−03

Dihydroceramides

0.79 (0.66, 0.94)

2

2

0

2

7.4E−03

Pyrimidine metabolism, cytidine containing

0.84 (0.74, 0.96)

5

2

0

2

1.3E−02

Eicosanoid

0.75 (0.59, 0.95)

3

2

0

2

1.7E−02

Chemical

0.87 (0.78, 0.98)

20

9

1

8

1.9E−02

Fatty Acid, monohydroxy

0.90 (0.82, 0.98)

19

5

0

5

2.0E−02

Androgenic steroids

0.80 (0.66, 0.97)

21

8

0

8

2.1E−02

Pantothenate and CoA metabolism

0.78 (0.63, 0.98)

2

1

0

1

3.0E−02

Gamma-glutamyl amino acid

0.93 (0.86, 1.00)

15

9

1

8

3.4E−02

Nicotinate and nicotinamide metabolism

0.86 (0.75, 0.99)

5

2

0

2

3.6E−02

Sphingosines

0.88 (0.78, 1.00)

2

1

0

1

3.6E−02

Purine metabolism, adenine containing

0.94 (0.88, 1.00)

5

2

0

2

4.0E−02

Fatty acid metabolism (acyl carnitine, dicarboxylate)

0.86 (0.73, 1.01)

4

2

0

2

4.6E−02

Sphingolipid synthesis

0.89 (0.79, 1.00)

3

2

0

2

4.6E−02

Phospholipid metabolism

0.92 (0.84, 1.00)

6

2

0

2

4.7E−02