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Table 1 Baseline characteristics by (sex-specific) quintiles of FABP-4 concentrations in control participants (n = 1324)

From: Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer

 

Quintile 1

Quintile 2

Quintile 3

Quintile 4

Quintile 5

P-trend

Quintile ranges in men

< 8.3 ng/mL

8.3– < 10.8 ng/mL

10.8– < 13.6 ng/mL

13.6– < 17.2 ng/mL

≥ 17.2 ng/mL

 

Quintile ranges in women

< 13.0 ng/mL

13.0– < 16.8 ng/mL

16.8– < 20.5 ng/mL

20.5– < 26.3 ng/mL

≥ 26.33 ng/mL

 

N

263

268

266

265

262

 

Male, n (%)

128 (47.9)

128 (47.6)

128 (47.8)

128 (47.6)

128 (47.9)

 

Female, n (%)

135 (51.3)

140 (52.2)

138 (51.9)

137 (51.7)

134 (51.1)

 0.93

Age, years

55.7 (7.0)

57.6 (7.1)

58.2 (7.4)

59.1 (6.2)

59.8 (6.6)

<0.0001

University degree, n (%)

48 (18.3)

56 (20.9)

50 (18.8)

41 (15.5)

40 (15.3)

0.12

Physically inactive, n (%)

40 (15.2)

50 (18.7)

73 (27.4)

61 (23.0)

71 (27.1)

0.001

Recreational and household physical activity, METs/week, median (p25, p75)

83.5 (48.5, 123.2)

78.9 (49.9, 118.7)

76.1 (42.6, 115.6)

75.7 (48.6, 115.5)

75.2 (42.0, 123.0)

0.58

Smoker, n (%)

75 (28.5)

61 (22.8)

57 (21.4)

69 (26.0)

66 (25.2)

0.69

Body mass index, kg/m2, mean (SD)

24.1 (3.1)

25.2 (3.1)

26.5 (3.4)

27.4 (3.3)

28.7 (4.3)

<0.0001

Waist circumference, cm, mean (SD)

82.6 (11.3)

85.9 (11.7)

89.1 (10.8)

91.1 (10.8)

95.4 (12.5)

< 0.0001

A-body shape index, mean (SD)

76.4 (5.6)

77.2 (6.2)

77.6 (5.7)

77.5 (5.4)

78.6 (5.5)

< 0.0001

Height, cm, mean (SD)

168 (9.0)

167 (9.1)

167 (9.3)

168 (9.8)

167 (8.9)

0.40

Diabetes at baseline, n (%)

7 (2.7)

9 (3.4)

10 (3.8)

10 (3.8)

11 (4.2)

0.02

Alcohol intake, g/day, median (p25, p75)

10.7 (2.1, 24.8)

7.4 (1.7, 23.6)

7.7 (1.5, 20.0)

9.2 (1.8, 24.5)

6.2 (1.5, 18.3)

0.13

Dietary factors

 Energy intake, kcal/day, median (p25, p75)

2085 (1751, 2557)

2070 (1663, 2464)

2005 (1650, 2417)

2094 (1656, 2512)

1934 (1564, 2392)

0.09

 Fiber, g/day, median (p25, p75)

23.8 (18.8, 30.0)

22.9 (18.0, 28.4)

22.9 (18.1, 27.2)

22.9 (18.0, 27.4)

22.6 (17.3, 26.9)

0.04

 Fruits and vegetables, g/day, median (p25, p75)

401.3 (262.3, 572.8)

397.9 (282.4, 575.4)

345.7 (241.0, 546.4)

360.9 (235.2, 535.0)

331.7 (213.6, 512.0)

0.01

 Red meat, g/day, median (p25, p75)

23.6 (13.0, 43.1)

24.1 (12.8, 43.3)

25.5 (12.5, 42.6)

26.9 (15.5, 45.3)

23.3 (13.3, 45.0)

0.77

 Processed meat intake, g/day, median (p25, p75)

41.4 (23.9, 70.5)

44.1 (23.8, 71.5)

46.4 (25.0, 74.3)

51.6 (31.1, 75.8)

48.2 (24.7, 79.7)

0.12

 Fish, g/day, median (p25, p75)

28.2 (13.5, 51.7)

25.9 (13.7, 48.7)

28.9 (16.1, 48.5)

28.9 (14.7, 52.3)

32.4 (16.4, 52.4)

0.49

 FABP-4, ng/mL, median (p25, p75)

7.9 (6.5, 11.2)

13.0 (9.7, 14.8)

17.0 (12.2, 18.4)

20.7 (15.3, 23.6)

27.2 (20.3, 31.9)

< 0.0001

  1. P for trend across quintiles from the generalized linear model for variables expressed as means, from the Jonckheere-Terpstra test for variables expressed as percentage, and from the Kruskal-Wallis test for variables expressed as median
  2. Mean (SD) unless indicated otherwise; FABP-4 Fatty acid binding protein 4, SD Standard deviation, p25 25th percentile, p75 75th percentile