Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer

Table 5 Mendelian randomization estimates between genetically predicted circulating FABP-4 concentrations and colorectal cancer risk

	OR per genetically predicted one standard deviation higher FABP-4 (95% CI)
	All SNPs (1 cis, 2 trans)				Cis-MR (1 SNP)		Cis-MR (2 SNPs)^a
	IVW	p-value	MR Egger	p-value	Wald ratio	p-value	IVW	p-value
CRC, overall	1.10 (0.95, 1.27)	0.20	1.27 (0.97, 1.68)	0.08	1.23 (0.97, 1.57)	0.09	1.18 (0.97, 1.43)	0.10
CRC, men	1.03 (0.84, 1.26)	0.77	1.19 (0.79, 1.78)	0.40	0.99 (0.71, 1.37)	0.94	0.94 (0.72, 1.23)	0.66
CRC, women	1.21 (0.98, 1.48)	0.08	1.46 (0.77, 2.78)	0.25	1.56 (1.09, 2.23)	0.02	1.48 (1.12, 1.95)	0.01
P-heterogeneity by sex		0.29		0.59		0.07		0.02

Mendelian randomization analyses of FABP-4 and risk of colorectal cancer based on a two-sample MR with SNP-FABP-4 associations for three SNPs (one cis, two trans) from SCALLOP consortium and SNP-CRC associations from GECCO, CORECT, and CCFR
Fixed-effects inverse-variance weighted estimates (IVW) or MR Egger for MR with all SNPs; Wald ratio estimates for cis-MR
OR Odds ratio, CI Confidence interval, FABP-4 Fatty acid binding protein 4, IVW Inverse-variance-weighted method, MR Mendelian randomization
^aCis-MR with two moderately correlated SNPs (rs77878271 and rs2011042), accounting for correlation matrix in IVW

ISSN: 1741-7015